Disappearance of 125l-Labelled Rat Growth Hormone in Nephrectomized and Sham Operated Rats

A. L. C. Wallace; B. D. Stacy

doi:10.1055/s-0028-1093764

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Horm Metab Res 1975; 7(2): 135-138
DOI: 10.1055/s-0028-1093764

Originals

Disappearance of ¹²⁵l-Labelled Rat Growth Hormone in Nephrectomized and Sham Operated Rats

A. L. C. Wallace , B. D. Stacy

C.S.I.R.O., Division of Animal Physiology, Blacktown, N.S.W., Australia

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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

¹²⁵I-labelled rat growth hormone (GH) was injected I.V. into rats immediately after nephrectomy or a sham operation. Serial blood samples were then taken for 2 hr from an indwelling arterial cannula.

The rates of removal of trichloracetic acid precipitable radioactivity and immunoreactive ¹²⁵I-GH were both significantly decreased in the nephrectomized rats.

Polyacrylamide gel eletrophoresis of plasma samples taken at 5 min and 120 min confirmed the observation that GH was removed from the circulation more slowly in the anephric rat.

It is concluded that in the rat the kidney contributes significantly to the clearance of GH from the blood.

Key words

Rat GH - GH Disappearance - Anephric Rats