Sex-Related Differences in Metabolism of 14C-Acetate in Response to Steroid Hormones by Isolated Rat Hepatocytes

R. A. Cole; S. Margolis

doi:10.1055/s-0028-1093749

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Horm Metab Res 1975; 7(3): 250-253
DOI: 10.1055/s-0028-1093749

Originals

Sex-Related Differences in Metabolism of ¹⁴C-Acetate in Response to Steroid Hormones by Isolated Rat Hepatocytes

R. A. Cole [*] , S. Margolis

Clayton Laboratories, Department of Medicine, and Department of Physiological Chemistry, The Johns Hopkins University, Baltimore, Maryland, USA

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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

No differences were found in the basal rate of lipid synthesis from ¹⁴C-acetate in hepatocytes isolated from mature male and virgin female rats. Lipid biosynthesis was stimulated 22-43% in the female 60 min after the addition of gonadal steroids. This rapid response suggests that subtle differences exist in the enzyme profile controlling the pathways of lipid metabolism in male and female rats. This difference may have been determined genetically or acquired after a period of sex-dependent hormonal stimulation beginning with puberty.

Key words

Lipid Synthesis - Isolated Rat Liver Cells - 17-β Estradiol - Diethylstilbesterol - Progesterone - Testosterone - Dexamethasone - Cytochrome P-450 Hydroxylation Enzyme System

1 R.A. Cole was a Henry Strong Denison schilar for the academic year 1973-1974. His present address is Department of Medicine, Beth Israel Hospital, Boston, Mass.