Experimental Hyperthyroidism in Dogs - Evaluation and Effects on Blood Sugar, Serum Insulin and Free Fatty Acids. during Glibenclamide Infusion Test[*]

Abstract

The effects of hyperthyroidism on the BS, serum IRI and FFA responses to HB 419 were studied. Hyperthyroidism, induced by 1-thyroxine administration, caused an increase in body temperature, respiratory rate, BS, serum FFA and PBI basal levels. Fasting serum cholesterol was reduced, and body weight, basal metabolic and heart rates, as well as basal serum insulin level failed to be affected.

The hypoglycaemic response to HB 419 was moderately facilitated by hyperthyroidism, despite of inducing an impairment in the insulin secretory response. Serum FFA profile, similarly shaped in hyperthyroid dogs and in euthyroid controls, was shifted upwards by hyperthyroid condition. Results are discussed.

Key words

Glibenclamide - Hyperthyroidism - Serum Immunoreactive Insulin - Serum Free Fatty Acids - Blood Sugar - Dogs

1 This work, presented partly at the Eighth Congress, Intern. Diabetes Fedn, Brussels, July 15-20, 1973 (Comm.No. 458), was sponsored by the "Consejo Nacional de Investigaciones Científicas y Técnicas", Argentina, and by Farbwerke Hoechst Argentina.

1 This work, presented partly at the Eighth Congress, Intern. Diabetes Fedn, Brussels, July 15-20, 1973 (Comm.No. 458), was sponsored by the "Consejo Nacional de Investigaciones Científicas y Técnicas", Argentina, and by Farbwerke Hoechst Argentina.

2 Established Investigator, "Consejo Nacional de Investigaciones Científicas y Técnicas", Argentina.

3 Post-graduate Fellow at the University of Buenos Aires, Argentina.