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Horm Metab Res 1976; 8(2): 106-108
DOI: 10.1055/s-0028-1093682
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Metergoline, a Specific Serotonin Antagonist, on Human Growth Hormone Response to Arginine and L-Dopa

A. E. Pontiroli , G. C. Viberti , A.  Tognetti , G.  Pozza
  • Cattedra di Patologia Medica dell'Università degli Studi di Milano, Ospedale San Raffaele, Milano-Segrate and Ospedale Luigi Sacco, Milano, Italy
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Publication Date:
23 December 2008 (online)

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Abstract

In seven normal subjects the repeated oral administration of metergoline, a specific antiserotonin agent, has enhanced HGH response to arginine infusion. Following placebo administration, arginine-induced HGH release was slightly but not significantly reduced; similarly, in eight metergoline treated subjects, HGH response to oral L-Dopa was slightly but not significantly reduced. HGH response to i.v. L-Dopa was not modified by the drug.

These results suggest that serotonin controls HGH response only in response to arginine, not to L-Dopa.

Key words

Metergoline - Serotonin - Growth Hormone - Arginine - L-Dopa - Antiserotonin Agents