Two experiments were performed to examine the effects of intramuscular estradiol administration
on the hepatic specific activities of some enzymes of lipid, carbohydrate and amino
acid metabolism in the immature fowl. Estradiol increased the specific activities
of the hepatic lipogenic enzymes, ATP citrate lyase and malate dehydrogenase (decarboxylating)
(NADP), but had no effects on the activities of the glycolytic, gluconeogenic and
amino acid metabolising enzymes except for pyruvate kinase and glutamate dehydrogenase
which were reduced in activity in both experiments. The results indicate that the
estrogen-induced increase in hepatic lipid biosynthesis is due to a specific effect
on lipid metabolism and not to a general increase in liver metabolism.
Domestic Fowl - Estradiol - Lipogenic Enzymes - Glycolytic Enzymes - Gluconeogenic
Enzyme - Amino Acid Metabolising Enzymes
