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Horm Metab Res 1976; 8(5): 379-383
DOI: 10.1055/s-0028-1093618
DOI: 10.1055/s-0028-1093618
Originals
© Georg Thieme Verlag KG Stuttgart · New York
Effects of Lithium on Inducible Enzymes of Rat Liver
Further Information
Publication History
Publication Date:
23 December 2008 (online)

Abstract
Chronic lithium administration to female rats results in elevation of serum corticoids, lowering of serum glucose and altered induction of liver enzymes. The Cortisol induction of tyrosine transaminase is increased selectively over that of tryptophan oxygenase. The glucose induction of glucokinase following a fast is increased by chronic lithium treatment but diminished by acute treatment. These results indicate that lithium may alter the glucose metabolic set-point in rats.
Key words
Lithium - Enzyme Induction - Glucocorticoids - Glucose
1 Present address: Dept. Biochemistry, Kansas State University, Manhattan, Kansas 66502