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Horm Metab Res 1976; 8(5): 379-383
DOI: 10.1055/s-0028-1093618
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© Georg Thieme Verlag KG Stuttgart · New York

Effects of Lithium on Inducible Enzymes of Rat Liver

G. W. Grier lll , L. C. Davis [*] , W. D. Pfeifer
  • Abraham Ribicoff Research Center, Norwich, Connecticut, U.S.A.
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Publication History

Publication Date:
23 December 2008 (online)

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Abstract

Chronic lithium administration to female rats results in elevation of serum corticoids, lowering of serum glucose and altered induction of liver enzymes. The Cortisol induction of tyrosine transaminase is increased selectively over that of tryptophan oxygenase. The glucose induction of glucokinase following a fast is increased by chronic lithium treatment but diminished by acute treatment. These results indicate that lithium may alter the glucose metabolic set-point in rats.

Key words

Lithium - Enzyme Induction - Glucocorticoids - Glucose

1 Present address: Dept. Biochemistry, Kansas State University, Manhattan, Kansas 66502