Insulin Effect on Proteolytic Activities in Rat Skeletal Muscle

H.-J. Röthig; N. Stiller; B. Dahlmann; H. Reinauer

doi:10.1055/s-0028-1093452

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Horm Metab Res 1978; 10(2): 101-104
DOI: 10.1055/s-0028-1093452

Originals

Insulin Effect on Proteolytic Activities in Rat Skeletal Muscle

H.-J. Röthig , N. Stiller , B. Dahlmann , H. Reinauer

Biochemical Department of the Diabetes-Forschungsinstitut, Düsseldorf, Germany

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Publikationsdatum:
23. Dezember 2008 (online)

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Abstract

Proteolytic activity has been measured in rat skeletal muscle by use of [¹⁴C]-hemoglobin as substrate. The activity of the alkaline proteinases increases during starvation and in diabetic state. In streptozotocin-diabetic animals the activity of alkaline proteases increases to 300% over a time of 21 days. Insulin treatment reverses the enhanced enzyme activity to normal level.

Key words

Adaptive Proteinases - Skeletal Muscle - Effect of Streptozotocin Diabetes - Fasting - Insulin Treatment