Horm Metab Res 1978; 10(2): 93-98
DOI: 10.1055/s-0028-1093450
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© Georg Thieme Verlag KG Stuttgart · New York

Effect of Fasting, Glucose, Amino Acids and Food Intake on In Vivo Insulin Release in the Chicken

J.  Simon , G.  Rosselin
  • Station de Recherches Avicoles (Institut National de la Recherche Agronomique), Centre de Recherches de Tours, 37380 Nouzilly, France
    Unité de Recherches de Diabétologie et d'Etudes Radioimmunologiques des Hormones Protéiques, U 55 (Institut National de la Santé et de la Recherche Médicale), Hôpital Saint Antoine, 75012 Paris, France
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Publikationsdatum:
23. Dezember 2008 (online)

Abstract

Insulin release was studied in vivo in the chicken using the radioimmunoassay previously described (Simon, Freychet and Rosselin 1974). An orally administered glucose load (2g/kg b.w.) stimulated insulin release and was rapidly metabolized. A prolonged fasting period (65 hr) increased both initial plasma glucose and initial plasma insulin levels and highly impaired the glucose tolerance. A fasting-impaired insulin release and/or a fasting tissue "insulin resistance" accounted for this fasting-impaired glucose tolerance. An orally administered amino acid mixture (1g/kg b.w.) stimulated insulin release to a very low extent. The effect was however sufficient to decrease the plasma glucose level. In combination with glucose, the oral amino acid load potentiated the effect of a dose of glucose on insulin release and highly improved the glucose tolerance. This synergism was still observed with the intake of a mixed and balanced diet. Therefore, except for some characteristics observed in the chicken which are discussed, the insulin regulation and the pancreatic β-cell function are qualitatively similar in the chicken and in mammals.