Subscribe to RSS
DOI: 10.1055/s-0028-1093433
© Georg Thieme Verlag KG Stuttgart · New York
Glycogen Metabolism in the Placenta of Streptozotocin Diabetic Rats[*]
Publication History
Publication Date:
23 December 2008 (online)
Abstract
Administration of STZ prior to mating, induced significant impairment in glycogen metabolism in term rat placentae. Glycogen retention was observed in the treated placentae, while glycogen synthetase activity was reduced. The glycogenolytic pathway seemed to proceed mainly through amyloglucosidase enzyme whose activity increased threefold. Glucose-6-phosphatase showed a moderate activation, mainly in the labyrinth zone, while Phosphorylase was slightly inhibited. These changes were accompanied by a decrease in placental insulin levels. The possible defensive role played by the placenta in cases of maternal hyperglycemia was postulated.
Key words
Streptozotocin - Placenta - Glucose - Glycogenesis - Glycogenolysis - Experimental Diabetes - Rats - Insulin
1 This research was supported by a grant from the Chief Scientist Office, Ministry of Health, Government of Israel.
1 This research was supported by a grant from the Chief Scientist Office, Ministry of Health, Government of Israel.
2 Established Investigator of the Chief Scientist Office, Ministry of Health, Israel.