Abstract
Effects of synthetic xenopsin on endocrine pancreas and gastric antrum in anesthetized
dogs were studied. Synthetic xenopsin was administered into the superior pancreaticoduodenal
artery and plasma insulin, glucagon and gastrin in the superior pancreaticoduodenal
vein and gastrin in the right gastroepiploic vein were measured radioimmunologically.
Administration of 10 µg of xenopsin per kg of body weight brought about a hyperglycemic
response and rapid and sharp elevations of the hormones in the pancreatic vein. Plasma
gastrin level in the gastric vein also showed an immediate and sharp increase following
xenopsin administration. Xenopsin appeared more potent inducer, of the glucagon. It
is concluded that xenopsin acts directly on endocrine pancreas and gastric antrum
to secrete their hormones.
Key words
Xenopsin - Insulin - Glucagon - Gastrin
