Horm Metab Res 1978; 10(5): 381-386
DOI: 10.1055/s-0028-1093396

© Georg Thieme Verlag KG Stuttgart · New York

Recovery of Immune System in Diabetic Mice after Treatment with Insulin

K.  Pavelić , M.  Slijepčević , Jasminka  Pavelić
  • "Rudjer Bošković" Institute, Department of Experimental Biology and Medicine, Zagreb, Yugoslavia, Department of Animal Physiology, Faculty of Natural Sciences and Mathematics, Zagreb, Yugoslavia
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Publication History

Publication Date:
23 December 2008 (online)


In mice with alloxan-induced diabetes, humoral and cellular immunological reactivity were weak. The number of leucocytes, and especially lymphocytes, was reduced, and the weight and cellularity of lymphatic organs were lower than in normal mice. Treatment of diabetic mice with insulin reversed morphological and functional deficiency of the immunological system. Observed depression of immunological functions was attributed to impaired transport of glucose into immunocompetent cells, rather than to toxic effects of alloxan.