Horm Metab Res 1978; 10(5): 365-369
DOI: 10.1055/s-0028-1093392

© Georg Thieme Verlag KG Stuttgart · New York

A Comparison between Diabetics Receiving a High or Low Daily Insulin Dosage

C. M. Asplin , M.  Hartog , D. J. Goldie [+] , K.G.M. M. Alberti [*] , P.  Smythe [*] , C.  Binder [o] , O. K. Faber [o]
  • University Department of Medicine, Bristol Royal Infirmary, Bristol, U.K.
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Publication History

Publication Date:
23 December 2008 (online)


Two groups of 8 diabetics, similar in many aspects, who required high (≥ 128 units) or low (≤ 32 units) total daily insulin dosage were compared during a 24 hour period.

C-peptide secretion was detected in all but one of the low dose group, but only in two of the high dose group. No significant differences in serum free and total insulin concentrations were detected and the patterns of blood metabolites were also similar, apart from higher blood glycerol concentrations in the low dose group. No significant differences in the binding characteristics of the antiinsulin antibodies were detected.

1 Department of Clinical Chemistry, Southmead Hospital, Bristol, U.K.

2 Faculty of Medicine, Chemical Pathology and Human Metabolism, General Hospital, Southampton, U.K.

3 Hvidøre Hospital, Klampenborg, Denmark