Thyroxine Inactivation by Starvation in Cultured Hepatocarcinoma Cells. Formation of Reverse Triiodothyronine

K. Sorimachi; J. Robbins

doi:10.1055/s-0028-1093385

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1978; 10(6): 528-531
DOI: 10.1055/s-0028-1093385

Originals

Thyroxine Inactivation by Starvation in Cultured Hepatocarcinoma Cells. Formation of Reverse Triiodothyronine

K. Sorimachi , J. Robbins

Clinical Endocrinology Branch National Institute of Arthritis, Metabolism and Digestive Diseases National Institutes of Health Bethesda, Maryland, U.S.A.

Abstract

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Abstract

The effect of starvation on thyroid hormone metabolism was studied in monkey hepatocarcinoma monolayer cultures. Nonphenolic ring monodeiodination of thyroxine, 3, 5, 3'-triiodothyronine and 3, 3'-diiodothyronine was accelerated. Since phenolic ring deiodination of 3, 3', 5'-triiodothyronine (reverse T₃) was unaffected, this metabolite accumulated in the medium during thyroxine metabolism. This suggests that increased serum reverse T₃ in malnourished humans may be caused by enhanced deiodination of thyroxine rather than decreased rT₃ catabolism.

Key words

Thyroxine - Inactivation - Starvation - Cultured Hepatocarcinoma Cells - Reverse Triiodothyronine

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