Abstract
Three major lipolytic factors, termed peaks 1, 2 and 3, according to their elution
sequence from Biogel P6 columns, have been identified in duck intestinal extracts.
The small molecular weight peaks 2 and 3, were even more lipolytically potent on chick
adipocytes than pancreatic glucagon; peak 1, called gut GLI, because of its cross-reactivity
in a radioimmunoassay for glucagon, modified the lipolytic activity of peak 2 and
pancreatic glucagon. It did so by modifying their capacity to stimulate cyclic AMP
production.
Peaks 2 and 3 exert their lipolytic effects via different intermediary pathways:
only peak 2 induced the formation of cyclic AMP.
Insulin in birds is devoid of any antilipolytic activity; this fundamental role may
be assumed by gut GLI.
Key words
Duck Gut Glucagon - Intestinal Lipolytic Agents - Inhibition - Cyclic AMP
