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© Georg Thieme Verlag KG Stuttgart · New York
Antilipolytic Nature of Gut GLI, and Mode of Action of Two Highly Potent Intestinal Lipolytic Species in Birds
23 December 2008 (online)
Three major lipolytic factors, termed peaks 1, 2 and 3, according to their elution sequence from Biogel P6 columns, have been identified in duck intestinal extracts. The small molecular weight peaks 2 and 3, were even more lipolytically potent on chick adipocytes than pancreatic glucagon; peak 1, called gut GLI, because of its cross-reactivity in a radioimmunoassay for glucagon, modified the lipolytic activity of peak 2 and pancreatic glucagon. It did so by modifying their capacity to stimulate cyclic AMP production.
Peaks 2 and 3 exert their lipolytic effects via different intermediary pathways: only peak 2 induced the formation of cyclic AMP.
Insulin in birds is devoid of any antilipolytic activity; this fundamental role may be assumed by gut GLI.
Duck Gut Glucagon - Intestinal Lipolytic Agents - Inhibition - Cyclic AMP