Horm Metab Res 1978; 10(6): 505-509
DOI: 10.1055/s-0028-1093380

© Georg Thieme Verlag KG Stuttgart · New York

Antilipolytic Nature of Gut GLI, and Mode of Action of Two Highly Potent Intestinal Lipolytic Species in Birds

Eva  Krug
  • Unité de Recherches sur la Glande Thyroide et la Régulation Hormonale I.N.S.E.R.M. et Equipe de Recherche Associée no. 449 C.N.R.S., Bicetre, France
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Publication History

Publication Date:
23 December 2008 (online)


Three major lipolytic factors, termed peaks 1, 2 and 3, according to their elution sequence from Biogel P6 columns, have been identified in duck intestinal extracts. The small molecular weight peaks 2 and 3, were even more lipolytically potent on chick adipocytes than pancreatic glucagon; peak 1, called gut GLI, because of its cross-reactivity in a radioimmunoassay for glucagon, modified the lipolytic activity of peak 2 and pancreatic glucagon. It did so by modifying their capacity to stimulate cyclic AMP production.

Peaks 2 and 3 exert their lipolytic effects via different intermediary pathways: only peak 2 induced the formation of cyclic AMP.

Insulin in birds is devoid of any antilipolytic activity; this fundamental role may be assumed by gut GLI.