Perfused Liver Carnitine Palmitoyl-Transferase  Activity and Ketogenesis in Streptozotocin Treated and Genetic Hyperinsulinemic Rats. Effect of Glucagon

R. Nosadini; F. Ursini; P. Tessari; A. Giengo; C. Gregolin

doi:10.1055/s-0028-1092794

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Horm Metab Res 1979; 11(12): 661-664
DOI: 10.1055/s-0028-1092794

Originals

Perfused Liver Carnitine Palmitoyl-Transferase Activity and Ketogenesis in Streptozotocin Treated and Genetic Hyperinsulinemic Rats. Effect of Glucagon

R. Nosadini¹ , F. Ursini² , P. Tessari¹ , A. Giengo¹ , C. Gregolin²

¹Department of Internal Medicine, Division of Gerontology and Metabolic Diseases
²Department of Biochemistry, University of Padua, Padova, Italy

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Publikationsdatum:
17. Dezember 2008 (online)

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Abstract

Perfused liver carnitine palmitoyl transferase (CPT) activity and ketone body output were determined in streptozotocin - treated and untreated Sprague-Dawley and Zucker rats. Streptozotocin enhanced liver ketogenic capacity and CPT activity in both these strains. No difference was observed in CPT activity or in ketone body production between the fatty and lean Zücker strains. Glucagon, added directly to the perfusate, had no influence on ketone body output and only in the livers of obese Zücker rats increased CPT activity.

Key words

Ketogenesis - Carnitine Palmitoyl Transferase (CPT) - Streptozotocin Diabetes - Genetic Obesity (Zücker Rat) - Glucagon - Insulin