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Horm Metab Res 1979; 11(9): 506-508
DOI: 10.1055/s-0028-1092771
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© Georg Thieme Verlag KG Stuttgart · New York

rT3 Production in Normal Man, Assessed from Variations in Serum rT3 During Short-Term rT3 Infusion

P.  Laurberg , J.  Weeke
  • Second University Clinic of Internal Medicine, Kommunehospitalet, Aarhus, Denmark
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Publication History

Publication Date:
17 December 2008 (online)

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Abstract

The metabolic clearance rate (MCR) of 3,3',5'-triiodothyronine (reverse T3, rT3) was estimated in normal human subjects by a modified noncompartmental method using the integrated increase in serum rT3 following intravenous infusion of 0.10 nmol/min rT3 for 4 hr.

The MCR-rT3 was calculated to be 102.8 ± 17.0 l/day and the daily rT3 disposal to be 33.0 ± 9.5 nmol (mean ± SD, n = 6). The MCR-rT3 compares well to that of previous studies employing tracer kinetic methods. The disposal rate of rT3 estimated in the present study is considerably lower than found in some previous studies. The discrepancy is due to differences in the measured levels of serum rT3 in normal subjects.

Key words

Iodothyronine Metabolism - Radioimmunoassay

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