Islet Transplantation in Experimental Diabetes of the Rat. VI. Rate of Regression in Diabetic Kidney Lesions after Isogeneic Islet Transplantation: Quantitative Measurements

Abstract

Intraportal transplantation of isogeneic adult islets in diabetic rats resulted in long-lasting amelioration of the metabolic disorder. The effect upon diabetes-induced kidney changes (enlargement of mesangial space, capillary changes, cell-proliferation) was examined quantitatively by morphometric studies. The major effect was a remarkable reduction of the mesangial space and re-widening of the capillary lumina. The number of endothelial cells was lowered. Regarding epithelial and mesangila cells no difference was observed between normal, diabetic and transplanted animals of age-matched groups.

Key words

Experimental Diabetes - Streptozotocin Intraportal Islet Transplantation - Glucose Metabolism Diabetic Renal Changes - Regression Rate of Renal Changes - Morphometric Studies

1 Thesis, Giessen

2 Supported by Deutsche Forschungsgemeinschaft SFB 87/D 7, Universität Ulm