Am J Perinatol 2008; 25(10): 657-659
DOI: 10.1055/s-0028-1090592
© Thieme Medical Publishers

Are Women Who Have Had a Preterm Singleton Delivery at Increased Risk of Preterm Birth in a Subsequent Twin Pregnancy?

Francesca L. Facco1 , Kate Nash1 , William A. Grobman1
  • 1Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois
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Publikationsverlauf

Publikationsdatum:
07. Oktober 2008 (online)

ABSTRACT

Our objective was to determine whether preterm birth of a singleton is associated with an increased risk of preterm birth of twins in a subsequent pregnancy. We identified all women who delivered a singleton followed by twins at Northwestern Memorial Hospital during a 10-year period. Using a cohort study design, we compared women with preterm singleton deliveries to women with term singleton deliveries with regard to their subsequent twin pregnancy outcomes. Two hundred ninety-three were identified who delivered a singleton followed by twins. Women who delivered a preterm singleton were significantly more likely to deliver subsequent preterm twins (73.9% versus 44.4%, odds ratio 3.5, 95% confidence interval 1.4 to 9.3). This significant difference persisted in multivariable analysis after controlling for ethnicity (adjusted odds ratio 3.3, 95% confidence interval 1.3 to 8.7). We concluded that preterm birth of a singleton is associated with an increased risk of preterm delivery in a subsequent twin gestation.

REFERENCES

Francesca L FaccoM.D. 

250 E. Superior, Suite 05-2175

Chicago, IL 60611

eMail: f-facco@md.northwestern.edu

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