Clin Colon Rectal Surg 2008; 21(4): 304-312
DOI: 10.1055/s-0028-1089947
© Thieme Medical Publishers

Chemoprevention for Colorectal Neoplasia

Alyssa D. Fajardo1 , 2 , Bruce W. Robb1
  • 1Department of Surgery/Colorectal Surgery, Indiana University School of Medicine, Indianapolis, Indiana
  • 2Current affiliation: Section of Colon and Rectal Surgery, Washington University School of Medicine, St. Louis, Missouri
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Publication History

Publication Date:
14 October 2008 (online)

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ABSTRACT

Colorectal cancer is a major cause of morbidity and mortality in industrialized societies and leads to significant treatment costs. Currently there are screening programs with fecal occult blood testing, radiographic, and endoscopic evaluation. Despite this, mortality from colorectal cancer has not improved dramatically. As such, attention has turned to finding agents to prevent carcinogenesis. The emerging field known as chemoprevention studies agents that target multiple steps in the development of adenomas and their subsequent transformation to colorectal carcinoma. There are multiple case control, cohort, and randomized controlled trials investigating the efficacy of fiber, calcium, vitamin D, folate, and nonsteroidal antiinflammatory drugs as chemopreventive agents against colorectal cancer.

REFERENCES

Bruce W RobbM.D. 

Department of Surgery/Colorectal Surgery, Indiana University School of Medicine

545 Barnhill Dr., Emerson Hall 503, Indianapolis, IN 46202

Email: brobb@iupui.edu