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DOI: 10.1055/s-0028-1089033
Thyroid globulin in fetal and maternal blood during pregnancy in nigerians
Objectives: To establish a reference range of thyroid binding globulin (TBG) values in normal fetuses and their mothers during pregnancy in Nigerian women.
Methods: Cross sectional analysis of blood samples collected from n=65 fetal cord samples between 13 and 40 weeks of gestation, and n=68 maternal blood samples between 12 and 40 weeks were performed using Elisa Kits, (Diagnostic Laboratories, Webster, Texas / USA), after separation, centrifugation and storage at –20 0C for thyroid binding globulin (TBG). For statistical analysis Student “t“ test and Wilcoxin test were used.
Result: There were significantly gradual increase of thyroid globulin level both in fetal cord and maternal blood as pregnancy advances (p<0.05)
Conclusion: This study confirms previous report that TBG level increases both in fetal cord and maternal blood as pregnancy advances.