A Promising Anticancer and Antimalarial Component from the Leaves of Bidens pilosa

Abstract

Bidens pilosa is used in folk medicine for various applications due to the presence of polyacetylenes, flavonoids, terpenoids, phenylpropanoids and others. Bioactivity-guided fractionation of different extracts of B. pilosa leaf showed potential in vitro anticancer and antimalarial activity and led to the identification of a potential marker compound, phenyl-1,3,5-heptatriyne. Erythrocyte osmotic fragility experiments revealed the various extracts as well as the marker component’s toxicity profiles on normal blood cells.

Abbreviations

ATCC:American Type Cell Culture Collection

DMSO:dimethyl sulphoxide

MTT:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

NBT:nitro blue tetrazolium

PES:phenazine ethosulphate

pLDH:parasite lactate dehydrogenase

ROS:reactive oxygen species

Key words

Bidens pilosa - Asteraceae - anticancer activity - antimalarial activity - phenyl-1,3,5-heptatriyne

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