Planta Med 2008; 74(15): 1823-1825
DOI: 10.1055/s-0028-1088321
Letter
Natural Products Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Dimeric Proanthocyanidins from the Roots of Ephedra sinica

Huaming Tao1 , 2 , Lishu Wang3 , 4 , Zhanchen Cui1 , Daqing Zhao3 , Yonghong Liu2
  • 1College of Chemistry, Jilin University, Changchun, P. R. China
  • 2Key Laboratory of Marine Bio-resources Sustainable Utilization, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China
  • 3College of Pharmacy, Changchun University of Chinese Medicine, Changchun, P. R. China
  • 4Jilin Provincial Academy of Chinese Medicine Sciences, Changchun, P. R. China
Further Information

Publication History

Received: May 10, 2008 Revised: August 3, 2008

Accepted: August 11, 2008

Publication Date:
30 October 2008 (online)

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Abstract

Two new dimeric proanthocyanidins, ephedrannin B (2) and mahuannin E (4), along with two known congeners, ephedrannin A (1) and mahuannin D (3), were isolated from the roots of Ephedra sinica Stapf. Based on NMR, MS, and CD analysis, the structures of the new compounds were deduced to be 5,7,4′-trihydroxyflavan-[4(α)→8,2(α)→O→7]-kaempferol (2) and 5,7,4′-trihydroxyflavan-[4(β)→8,2(β)→O→7]-epi-afzelechin (4). The compounds 1 – 4 were evaluated for cytotoxicity against three tumor cell lines (SGC-7901, HepG2, and HeLa), and 2 was found to be significantly active.

References

Dr. Yonghong Liu

Key Laboratory of Marine Bio-resources Sustainable Utilization

South China Sea Institute of Oceanology

Chinese Academy of Sciences

No. 164 West Xingang Road

Guangzhou 510301

People’s Republic of China

Phone: +86-20-8902-3244

Fax: +86-20-8445-1672

Email: yonghongliu@scsio.ac.cn