Planta Med 2008; 74(14): 1749-1750
DOI: 10.1055/s-0028-1088317
Letter
Natural Products Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

A New Monoterpene Alkaloid and Other Constituents of Plumeria acutifolia

Emad M. Hassan1 , Abdelaaty A. Shahat2 , Nabawya A. Ibrahim3 , Arnold J. Vlietinck4 , Sandra Apers4 , Luc Pieters4
  • 1Department of Medicinal and Aromatic Plants, National Research Centre, Dokki, Cairo, Egypt
  • 2Department of Phytochemistry, National Research Centre, Dokki, Cairo, Egypt
  • 3Department of Pharmacognosy, National Research Centre, Dokki, Cairo, Egypt
  • 4Department of Pharmaceutical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Belgium
Further Information

Publication History

Received: June 8, 2008 Revised: July 18, 2008

Accepted: July 30, 2008

Publication Date:
30 October 2008 (online)

Abstract

Phytochemical investigation of the methanolic extract of Plumeria acutifolia (Apocynaceae) leaves has led to the isolation and identification by spectroscopic means of a new monoterpene alkaloid, (R)-4′-{(S)-1-hydroxyethyl)-5,6-dihydro-5′H-spiro[cyclopenta[c]pyridine-7,2′-furan}-5′-one, for which the name plumerianine was adopted, the iridoid 15-demethylplumeride, and three known triterpenes, i. e., lupeol, uvaol and ursolic acid.

References

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  • 2 Burns D, Reynolds W F, Buchanan G, Reese P B, Enriquez R G. Assignment of 1H and 13C spectra and investigation of hindered side-chain rotation in lupeol derivatives.  Magn Reson Chem. 2000;  38 488-93.
  • 3 Siddiqui S, Hafeez F, Begum S, Siddiqui B. Kaneric acid, a new triterpene from the leaves of Nerium oleander. .  J Nat Prod. 1986;  49 1086-90
  • 4 Deng J Z, Starch S R, Hecht S M. DNA polymerase β inhibitors from Baeckea gunniana. .  J Nat Prod. 1999;  62 1624-6
  • 5 Hänsel R, Sticher O. Pharmakognsie-Phytopharmazie, 7th edition.  Heidelberg:. Springer-Verlag;  2004 907-8

Dr. Emad M. Hassan

Department of Medicinal and Aromatic Plants

National Research Centre

12311 Dokki

Cairo

Egypt

Phone: +20-127-152 706

Fax: +20-233-370 931

Email: emadnrc@yahoo.com

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