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Synfacts 2009(3): 0245-0245  
DOI: 10.1055/s-0028-1087697
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of Platencin

Contributor(s): Philip Kocienski, Indu Dager
K. C. Nicolaou*, Q.-Y. Toh, D. Y.-K. Chen*
Institute of Chemical and Engineering Sciences, Singapore
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Publication History

Publication Date:
19 February 2009 (online)

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Significance

Platencin targets a broad range of bacteria including drug-resistant strains such as MRSA (methicillin-resistant Staphylococcus aureus), vancomycin-resistant enterococci and Streptococcus pneumoniae. Platencin possesses dual activity and inhibits the fatty acids synthesis pathway in bacteria by binding to both the ­enzymes FabH and FabF.