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Synlett 2009(2): 287-291  
DOI: 10.1055/s-0028-1087671
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Reduction of Phosphinites, Phosphinates, and Related Species with DIBAL-H

Carl A. Busacca*, Teresa Bartholomeyzik, Sreedhar Cheekoori, Ravinder Raju, Magnus Eriksson, Suresh Kapadia, Anjan Saha, Xingzhong Zeng, Chris H. Senanayake
Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA
e-Mail: carl.busacca@boehringer-ingelheim.com;
Further Information

Publication History

Received 1 September 2008
Publication Date:
15 January 2009 (online)

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Abstract

Diisobutylaluminium hydride has been found to be an excellent reducing agent for phosphinites, phosphinates, and chlorophosphines. By performing reductions in situ, direct synthesis of secondary phosphine boranes from Grignard reagents has been achieved without isolation or purification of any intermediates.

Key words

phosphorus - phosphines - phosphine boranes - reductions

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