Synfacts 2008(12): 1250-1250  
DOI: 10.1055/s-0028-1087294
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Cannabinoids

Contributor(s): Philip Kocienski, Indu Dager
J. A. Teske, A. Deiters*
North Carolina State University, Raleigh, USA
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20. November 2008 (online)


The psychotropic, antiemetic, analgesic, and anticonvulsant properties of Cannabis plants have been known since the third millennium BC. Cannabinoids target two cell receptors: the central cannabinoid receptor CB1 and the peri­pheral cannabinoid receptor CB2. A [2+2+2] cyclo­trimerization reaction gave access to three different cannabinoid analogues from the same intermediate, providing a flexible synthetic route.