Subscribe to RSS
DOI: 10.1055/s-0028-1086053
© Sonntag Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG
Porträt einer Arzneipflanze
Die Juckbohne ist eine tropische Kletterpflanze, die im Ayurveda-System eine Rolle spielt. Pharmakologisch wichtigster Inhaltsstoff ist L-Dopa, das sich vor allem im Samen findet. So zielen entsprechend viele Studien auf den Einsatz geeigneter Extrakte bei Morbus Parkinson.Publication History
Publication Date:
27 August 2008 (online)
Zusammenfassung
Mucuna pruriens (L.) DC., die Kratz- oder Juckbohne aus der Familie der Fabaceae, wird seit Langem als Arzneipflanze in der Ayurveda zur Behandlung von Störungen des Nervensystems und anderer Erkrankungen eingesetzt. Die ausgeprägten Wirkungen der Samenextrakte gegen die Symptome von Morbus Parkinson lassen sich auf den hohen L-Dopa-Gehalt (syn. Levodopa) zurückführen, aber auch neuroprotektive Wirkungen scheinen eine Rolle zu spielen. Die Nebenwirkungen der Extrakte sind geringer im Vergleich zu synthetischem Levodopa; Ursache hierfür dürften Begleitstoffe sein. M. pruriens könnte in der Zukunft – nach weiteren, genauen Untersuchungen – eine große Bedeutung in der Behandlung des Morbus Parkinson erlangen.
Summary
Portrait of a medicinal plant: Mucuna pruriens (L.) DC.
Mucuna pruriens (L.) DC., the cowhage or velvet bean from the Fabaceae family, has been known in Ayurveda as a herbal remedy for diseases of the nervous system and other disorders. The pronounced effects of the seed extracts of M. pruriens against the symptoms of Parkinson’s disease can be explained with the high L-Dopa content (syn. levodopa), but neuroprotective effects seem to play a role as well. Less adverse effects of the seed extracts have been observed compared to synthetic levodopa. This may be due to accompanying ingredients of the plant extracts. M. pruriens might become very important in the treatment of Parkinson’s disease in the future, but further and more detailed studies are needed.
Schlüsselwörter
Mucuna pruriens - Fabaceae - Morbus Parkinson - L-Dopa - Levodopa - Neuroprotektion - Juckbohne - Kratzbohne
Key words
Mucuna pruriens - Fabaceae - Parkinson’s disease - L-Dopa - levodopa - neuroprotection - velvet bean - cowhage
Literatur
1 Genaue Struktur nicht bekannt;
2 nicht in Samendroge enthalten
- 1 Aguiyi JC, Guerranti R, Pagani R, Marinello E. Blood chemistry of rats pretreated with Mucuna pruriens seed aqueous extract MP101UJ after Echis carinatus venom challenge. Phytother Res. 2001; 15 712-714
- 2 Ahlskog JE. Challenging conventional wisdom: The etiologic role of dopamine oxidative stress in Parkinson’s disease. Mov Disorders. 2005; 20 271-282
- 3 Arthur RP, Shelley WB. Experimental evidence for an enzymatic basis for itching in man. Nature. 1955; 175 901-902
- 4 Aswar U, Aswar M, Bodhankar SL, Thakurdesai PA. Effect of Mucuna pruriens on haloperidol induced sensitization of catalepsy. Pharmacologyonline. 2006; 2 356-362
- 5 Bell EA, Nulu JR, Cone C. L-Dopa and L-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, a new imino acid, from seeds of Mucuna mutisiana . Phytochemistry. 1971; 10 2191-2194
- 6 Berg D, Youdim MB, Riederer P. Redox imbalance. Cell Tissue Res. 2004; 318 201-213
- 7 Betancur-Ancona DA, Chel-Guerrero LA, Bello-Pérez LA, Dávila-Ortiz G. Isolation of velvet bean (Mucuna pruriens) starch: physicochemical and functional properties. Starch. 2002; 54 303-309
- 8 Birkmayer GJ, Birkmayer W. Stimulation of endogenous L-Dopa biosynthesis – a new principle for the therapy of Parkinson’s disease. The clinical effect of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotidephosphate (NADPH). Acta Neurol Scand. 1989; 126 (Suppl) 183-187
- 9 Bowden K, Brown BG, Batty JE. 5-Hydroxytryptamine: its occurrence in cowhage. Nature. 1954; 174 925-926
- 10 Broadbent JL. Observations on itching produced by cowhage, and on the part played by histamine as a mediator of the itch sensation. Brit J Pharmacol. 1953; 8 263-270
- 11 Damodaran M, Ramaswamy R. CCLXI. Isolation of l-3:4-dihydroxy-phenylalanine from the seeds of Mucuna pruriens . Biochem. 1937; 31 2149-2152
- 12 Daxenbichler ME, Van Etten CH, Hallinan EA, Earle FR. Seeds as sources of L-Dopa. J Med Chem. 1971; 14 463-465
- 13 Di Patrizi L, Rosati F, Guerranti R, et al.. Structural characterization of the N-glycans of gpMuc from Mucuna pruriens seeds. Glycoconj J. 2006; 23 599-609
- 14 Donati D, Lampariello LR, Pagani R, et al.. Antidiabetic oligocyclitols in seeds of Mucuna pruriens . Phytother Res. 2005; 19 1057-1060
-
15 Eilittä M, Bressani R, Carew LB, et al..
Mucuna as a food and feed crop . In: Flores BM, Eilittä M, Myhrman R, Carew LB, Carsky RJ, eds. Food and feed from Mucuna: Current uses and the way forward. Tegucigalpa, Honduras; CIDICCO 2002: 18-46 - 16 Fairbrothers D, Kirby E, Lester RM, et al.. Mucuna pruriens-associated pruritus – New Jersey. JAMA. 1986; 255 313
- 17 Foley PB. Beans, roots and leaves. A history of the chemical therapy of Parkinsonism. Marburg; Tectum Verlag 2003
- 18 Fujii Y. Allelopathy in the natural and agricultural ecosystems and isolation of potent allelochemicals from velvet bean (Mucuna pruriens) and hairy vetch (Vicia villosa). Biol Sci Space. 2003; 17 6-13
- 19 Ghosal S, Singh S, Bhattacharya SK. Alkaloids of Mucuna pruriens – chemistry and pharmacology. Planta Med. 1971; 19 279-284
- 20 Grover JK, Vats V, Rathi SS, Dawar R. Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. J Ethnopharmacol. 2001; 76 233-238
- 21 Guerranti R, Aguiyi JC, Neri S, et al.. Proteins from Mucuna pruriens and enzymes from Echis carinatus venom. Characterization and cross-reactions. J Biol Chem. 2002; 277 17072-17078
- 22 Guerranti R, Aguiyi JC, Ogueli IG, et al.. Protection of Mucuna pruriens seeds against Echis carinatus venom is exerted through a multiform glycoprotein whose oligosaccharide chains are functional in this role. Biochem Biophys Res Commun. 2004; 323 484-490
- 23 Hasan SQ, Sherwani MR, Ahmad I, et al.. Epoxy acids for Mucuna prurita seed oil. J Ind Chem Soc. 1980; 57 920-923
- 24 HP-200 in Parkinson’s Disease Study Group . An alternative medicine treatment for Parkinson’s disease: results of a multicenter clinical trial. J Altern Complement Med. 1995; 1 249-255
- 25 Hussain G, Manyam BV. Mucuna pruriens proves more effective than L-Dopa in Parkinson’s disease animal model. Phytother Res. 1997; 11 419-423
- 26 Infante ME, Perez AM, Simao MR, et al.. Outbreak of acute toxic psychosis attributed to Mucuna pruriens . Lancet. 1990; 336 1129
- 27 Katzenschlager R, Evans A, Manson A, et al.. Mucuna pruriens in Parkinson’s disease: a double blind clinical and pharmacological study. J Neurol Neurosurg Psychiatry. 2004; 75 1672-1677
-
28 Lorenzetti F, MacIsaac S, Arnason JT, et al..
The phytochemistry, toxicology, and food potential of velvetbean (Mucuna Adans. spp., Fabaceae) . In: Buckles D, Etèka A, Osinane O, Galibo M, Galiano N, eds. Cover crops in West Africa Contributing to a sustainable agriculture. Ottawa; IDRC Publications 1998: 14-36 http://www.idrc.ca/en/ev-31916-201-1-DO_TOPIC.html - 29 Mahajani SS, Doshi VJ, Parikh KM, Manyam BV. Bioavailability of L-Dopa from HP-200 – a formulation of seed powder of Mucuna pruriens (Bak): a pharmacokinetic and pharmacodynamic study. Phytother Res. 1996; 10 254-256
- 30 Manyam BV. Paralysis agitans and levodopa in Ayurveda: Ancient Indian medical treatise. Mov Disorders. 1990; 5 47-48
- 31 Manyam BV, Sánchez-Ramos JR. Traditional and complementary therapies in Parkinson’s disease. Adv Neurol. 1999; 80 565-574
- 32 Manyam BV, Dhanasekaran M, Hare TA. Neuroprotective effects of the antiparkinson drug Mucuna pruriens . Phytother Res. 2004; 18 706-712
- 33 Manyam BV, Dhanasekaran M, Hare TA. Effect of antiparkinson drug HP-200 (Mucuna pruriens) on the central monoaminergic neurotransmitters. Phytother Res. 2004; 18 97-101
- 34 Miller ER. Dihydroxyphenylalanine, a constituent of the velvet bean. J Biol Chem. 1920; 44 481-486
- 35 Misra L, Wagner H. Alkaloidal constituents of Mucuna pruriens seeds. Phytochemistry. 2004; 65 2565-2567
- 36 Misra L, Wagner H. Lipid derivatives from Mucuna pruriens seeds. Ind J Chem. 2006; 45B 801-804
- 37 Misra L, Wagner H. Extraction of the bioactive principles from Mucuna pruriens seeds. Ind J Biochem Biophys. 2007; 44 56-60
- 38 Nath C, Gupta GP, Bhargava KP, et al.. Study of antiparkinsonian activity of Mucuna prurita hook. Ind J Pharmacol. 1981; 13 94-95
- 39 Nerdinger P. Phytochemische und pharmakologische Untersuchungen der Arzneipflanzen Phyllanthus amarus Schumach. & Thonn., Mucuna pruriens L. und Cissus quadrangularis L. [Dissertation]. München; LMU 2001
- 40 Neuwinger HD. Afrikanische Arzneipflanzen und Jagdgifte. Stuttgart; Wiss. Verlagsgesellschaft 1998
- 41 Okuda K, Kotake Y, Ohta S. Parkinsonismpreventing activity of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives in C57BL mouse in vivo. Biol Pharm Bull. 2006; 29 1401-1403
-
42 Phillips J. Medical botany (»Dolichos pruriens«). London; 1790-1793 468-471
- 43 Radad K, Gille G, Rausch WD. Short review on dopamine agonists: insight into clinical and research studies relevant to Parkinson’s disease. Pharmacol Rep. 2005; 57 701-712
- 44 Rajendran V, Joseph T, David J. Reappraisal of dopaminergic aspects of Mucuna pruriens and comparative profile with L-Dopa in cardiovascular and central nervous system in animals. Ind Drugs. 1996; 33 465-472
- 45 Rajeshwar Y, Kumar GP, Gupta M, Mazumder UK. Studies on in vitro antioxidant activities of methanol extract of Mucuna pruriens (Fabaceae) seeds. Eur Bull Drug Res. 2005; 13 31-39
- 46 Rajeshwar Y, Gupta M, Mazumder UK. In vitro lipid peroxidation and antimicrobial activity of Mucuna pruriens seeds. Iran J Pharmacol Ther. 2005; 4 32-35
- 47 Rajeshwar Y, Gupta M, Mazumder UK. Antitumor activity and in vivo antioxidant status of Mucuna pruriens (Fabaceae) seeds against Ehrlich Ascites Carcinoma in Swiss albino mice. Iran J Pharmacol Ther. 2005; 4 46-53
- 48 Rathi SS, Grover JK, Vats V. The effect of Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism. Phytother Res. 2002; 16 236-243
- 49 Rehr SS, Janzen DH, Feeny PP. L-Dopa in legume seeds: a chemical barrier to insect attack. Science. 1973; 181 81-82
- 50 Sathiyanarayanan L, Arulmozhi S. Mucuna pruriens Linn. A comprehensive review. Pharmacognosy Rev. 2007; 1 157-162
- 51 Shults CW, Haas RH, Passov D, Bal MF. Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann Neurol. 1997; 42 261-264
- 52 Siddhuraju P, Vijayakumari K, Janardhanan K. Chemical composition and protein quality of the little-known legume, velvet bean (Mucuna pruriens (L.) DC.) J Agric Food Chem. 1996; 44 2636-2641
- 53 Siddhuraju P, Becker K. Rapid reversed-phase high performance liquid chromatographic method for the quantification of L-Dopa (L-3,4-dihydroxyphenylalanine), non-methylated and methylated tetra-hydroisoquinoline compounds from Mucuna beans. Food Chem. 2001; 72 389-394
-
54 Szabo NJ, Tebbett IR.
The chemistry and toxicity of Mucuna species . In: Flores BM, Eilittä M, Myhrman R, Carew LB, Carsky RJ, eds. Food and feed from Mucuna: Current uses and the way forward. Tegucigalpa, Honduras; CIDICCO 2002: 120-141 - 55 Szabo NJ. Indolealkylamines in Mucuna species. Trop Suptrop Agroecosyst. 2003; 1 295-307
- 56 Texeira AA, Rich EC, Szabo NJ. Water extraction of L-Dopa from Mucuna bean. Trop Subtrop Agroecosyst. 2003; 1 159-171
- 57 Tharakan B, Dhanasekaran M, Mize-Berge J, Manyam BV. Anti-parkinson botanical Mucuna pruriens prevents levodopa induced plasmid and genomic DNA damage. Phytother Res. 2007; 21 1124-1126
- 58 Tomita-Yokotani K, Fujii Y, Hashimoto H, Yamashita M. Reduced allelopathic inhibition of lettuce (Lactuca sativa) growth caused by velvet bean (Mucuna pruriens) under 3D-clinorotation. Biol Sci Space. 2003; 17 14-17
- 59 Tripathi YB, Upadhyay AK. Antioxidant property of Mucuna pruriens . Linn Curr Sci. 2001; 80 1377-1378
- 60 Tripathi YB, Upadhyay AK. Effect of the alcohol extract of the seeds of Mucuna pruriens on free radicals and oxidative stress in albino rats. Phytother Res. 2002; 16 534-538
- 61 Vadivel V, Janardhanan K. Nutritional and antinutritional characteristics of seven south Indian wild legumes. Plant Foods Hum Nutr. 2005; 60 69-75
- 62 Vaidya AB, Rajagopalan TG, Mankodi NA, et al.. Treatment of Parkinson’s disease with cowhage plant – Mucuna pruriens Bak. Neurol (India). 1978; 26 171-176
- 63 Vaidya RA, Sheth AR, Aloorkar SD, et al.. The inhibitory effect of the cowhage plant – Mucuna pruriens – and L-Dopa on chlorpromazine-induced hyperprolactinaemia in man. Neurol (India). 1978; 26 177-178
- 64 Wilmot-Dear CM. A revision of Mucuna (Leguminosae-Phaseoleae) in China and Japan. Kew Bull. 1984; 39 23-65
Dr. Klaus Peter Latté
Warägerweg 21
13595 Berlin
Email: klauspeter.latte@lycos.de