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Neuropediatrics 1979; 10(4): 395-400
DOI: 10.1055/s-0028-1085341
Case report

© 1979 by Thieme Medical Publishers, Inc.

Krabbe's Disease with Unusual Clinical and Morphological Features

F. Gullotta1 , L. Pavone2 , F. Mollica2 , S. Grasso3 , C. Valenti4
  • 1Institut für Neuropathologie der Universität Bonn (Fed. Rep. of Germany)
  • 2Clinica Pediatrica, Italy
  • 3Istituto di Anatomia Patologica della Universitá di Catania, Italy
  • 4Centro Medico Diagnostico, Roma, Italy
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Publication History

1978

1979

Publication Date:
18 November 2008 (online)

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Abstract

A progressive encephalo-pathy appeared in two sibs aged 7 and 5 months. The children died at 23 respectively 29 months of age. Autopsy of the second child disclosed a severe demyelination involving the whole brain. Only few globoid cells were identified. Ultrastructural and biochemical investigations confirmed the diagnosis of Krabbe's disease.

Keyword

Unusual Krabbe's disease