Planta Med 2008; 74 - PD5
DOI: 10.1055/s-0028-1084680

Relief from atopic dermatitis by Uniflavon™

DS Kim 1, EJ Son 1, MR Kim 1, JB Nam 1, MS Oh 1, SG Do 1, YC Lee 1, J Cha 1, SS Woo 1
  • 1Unigen Inc., Cheonan, Chungnam 330–863, Korea

We screened plants for anti-allergic effects by evaluating the amounts of histamine and leukotrienes released after guinea pig lung mast cells activation[1]. The results showed that Scutellaria baicalensis roots and Phyllostachys edulis leaves had strong inhibitory effects. Bioassay-guided fractionation led to two flavonoid compounds, baicalin from Scutellaria baicalenesis roots and isoorientin from Phyllastachys edulis leaves. Based on these compounds, we developed two standardized extracts, SSBE from S. baicalensis and SPEE from P. edulis. SSBE as well as SPEE remarkably inhibited histamine and leukotrienes release in a dose-dependent manner.

We also further developed Uniflavon™ by combining these extracts at a 1:2 ratio; the resulting combination had a stronger activity than either extract alone.

A human clinical study was performed to assess safety as well as efficacy on atopic dermatitis via clinical, self and instrumental assessments [2]. Twenty volunteers received a cream formulation containing 2.0% Uniflavon™ and were evaluated for 2 and 4 weeks. Results indicate that Uniflavon™ significantly improved all symptoms tested and showed no adverse effects.

References: 1. Andersson, P. (1980) Allergy 35: 65–71.

2. Kunz, B. et al (1997) Dermatology 195:10–19