Planta Med 2008; 74 - PB157
DOI: 10.1055/s-0028-1084501

New peltogynoids from Acacia nilotica

AA Ahmadu 1, 2, A Agunu 3, R Grougnet 4, P Magiatis 2, AL Skaltsounis 2, F Tillequin 4
  • 1Department of Pharmaceutical chemistry, Niger-Delta University, Wilberforce Island, Yeanagoa, Nigeria
  • 2Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece
  • 3Department of Pharmacognosy and Drug development, Faculty of Pharmaceutical sciences, Ahmadu Bello University, Zaria 810261, Nigeria
  • 4Laboratoire de Pharmacognosie de l'Université René Descartes, UMR/CNRS 8638, Faculté de Pharmacie, 4 Avenue de l'Observatoire, F-75006 Paris, France

The genus Acacia (Leguminosae, subfamily Mimosoideae) includes some 1400 species of trees and shrubs widespread throughout the warm arid and semi-arid regions of the world. Acacia nilotica (L.) Delile belongs to the subgenus Acacia. It naturally occurs in tropical Africa, from Senegal and Egypt southwards to Mozambique and Natal, and also in Asia, from Arabia to India and Burma. A. nilotica is a more or less shrubby tree 5–20m high. This species is widely used in traditional medicine in Africa. Repeated column chromatography over silica gel of the CHCl3 soluble part of the EtOH extract obtained from the stem bark of Acacia nilotica, resulted in the isolation of the two novel peltogynans, acanilol I (1) and II (2), together with the known triterpene lupenone. The structures of the novel compounds were established on the basis of mass spectrometry and NMR experiments [1].

References: 1. This work is a corrigendum of Planta Med (2007) 73:944, where compounds 1 and 2 were erroneously reported as isolated from Ficus sycomorus