Planta Med 2008; 74 - PB136
DOI: 10.1055/s-0028-1084481

New indolic compounds from the stem bark of Isolona hexaloba (Annonaceae)

F Sénéjoux 1, IN Bajin 1, 2, B Akendengué 2, P Champy 1
  • 1Laboratoire de Pharmacognosie, UMR CNRS 8076 BioCIS, Faculté de Pharmacie Paris-Sud 11, 92296 Châtenay-Malabry, France
  • 2Laboratoire de Pharmacologie, Faculté de Médecine de l'Université des Sciences de la Santé, BP4009, Libreville, Gabon

Isolona hexaloba is a tall tree of equatorial Africa forests, which is traditionaly used against malaria. The genus Isolona is a source of bis-benzylisoquinolines [1] and of prenylated indoles which were proposed to be chemotaxonomical markers [2,3]. Fractionnation of a stem bark chloromethylenic extract of Isolona hexaloba yielded ubiquitary fatty acids, several sterols, caryophyllene oxide as a mixture of diastereoisomers, along with several known oxoaporphines. More interestingly, a series of indolic compounds was obtained, three of them bearing a short alkyl chain in position 5 or 6, closely related to structures previously described in Isolona or Monodora species (e.g. A) [4], and two being original dimeric prenylated diastereoisomers (B). Biological study of these molecules is actually being performed.

A

B

1. Lebœuf, M., et al. (1982) Phytochemistry 21: 2783–2813.

2. Achenbach, H., et al. (1995) Phytochemistry 40: 967–973.

3. Mankagara, J.J., et al. (2004) Phytochemistry 65: 227–232.

4. Nkunya, M.H.H., et al. (2004) Nat. Prod. Res. 18: 253–258.