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DOI: 10.1055/s-0028-1084481
New indolic compounds from the stem bark of Isolona hexaloba (Annonaceae)
Isolona hexaloba is a tall tree of equatorial Africa forests, which is traditionaly used against malaria. The genus Isolona is a source of bis-benzylisoquinolines [1] and of prenylated indoles which were proposed to be chemotaxonomical markers [2,3]. Fractionnation of a stem bark chloromethylenic extract of Isolona hexaloba yielded ubiquitary fatty acids, several sterols, caryophyllene oxide as a mixture of diastereoisomers, along with several known oxoaporphines. More interestingly, a series of indolic compounds was obtained, three of them bearing a short alkyl chain in position 5 or 6, closely related to structures previously described in Isolona or Monodora species (e.g. A) [4], and two being original dimeric prenylated diastereoisomers (B). Biological study of these molecules is actually being performed.
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