Planta Med 2008; 74 - PB130
DOI: 10.1055/s-0028-1084475

Hydroxylated Sclerosporin derivatives from a cytotoxic Wardomyces inflatus extract

C Almeida 1, S Kehraus 1, GM König 1
  • 1Bonn University, Institute for Pharmaceutical Biology, Nussallee 6, 53115 Bonn, Germany

The marine-derived fungus Wardomyces inflatus was isolated from the green alga Enteromorpha sp. Cultivation on a biomalt medium with added sea salt yielded an extract cytotoxic toward cancer cells. To date, we have isolated from this extract sclerosporin and four new hydroxylated sclerosporin derivatives, namely 8-hydroxy sclerosporin, 11-hydroxy sclerosporin, 12-hydroxy sclerosporin and 15-hydroxy sclerosporin. Sclerosporin is a rare antifungal and sporogenic cadinane-type sesquiterpene [1,2].

Aknowledgements: Financial support from FCT (Science and Technology Foundation, Portugal), and BMBF (project No. 03F0415A).

References: 1. Katayama M., et al. (1983) Tetrahedron Lett. 24:1703–1706. 2. Datta K., et al. (2007)J. Nat. Med. 61:391–396.