Planta Med 2008; 74 - PB107
DOI: 10.1055/s-0028-1084452

Phytotoxic tetranorditerpenoids from the fungus Sclerotinia homoeocarpa, causal agent of dollar spot in turfgrass

HMT Herath 1, WHMW Herath 1, SO Duke 2, M Tomaso-Peterson 3, NPD Nanayakkara 1
  • 1National Center for Natural Products Research, Research, Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677
  • 2Natural Products Utilization Research Unit, USDA-ARS, University, MS 38677
  • 3Department of Entomology and Plant Pathology, Mississippi State University, Mississippi State, MS 39762

Sclerotinia homoeocarpa is the causal agent of „dollar spot,“ the most prevalent disease of turfgrass in North America [1]. Chemical investigation of the fermentation broth of S. homoeocarpa led to the isolation of nine new phytotoxic tetranorditerpenoid dilactones (2 - 10), together with four previously reported norditerpenoids dilactones [2,3] (1, 11), and two known putative biosynthetic intermediates oidiolactone-E (12) [4] and 13 [5].

Acknowledgements: The authors sincerely thank Bob Johnson, USDA-ARS, for his technical assistance in this research.

References: 1 Couch, HB. (1995) Diseases of Turfgrasses. 3rd ed. Krieger Publishing Company. Malabar, Florida. pp. 65–69. 2. Yoneyama K, et al. (2000) Jpn. Kokai Tokkyo Koho. JP 2000247979 A 20000912. 3. Pettit GR, et al. (2003)J. Nat. Prod. 66: 276–278. 4. Ichikawa K, et al. (2001)J. Antibiot. 54: 697–702. 5. Ellestad GA, et al. (1971) Tetrahedron Lett. 497–500.