A new sesquiterpene lactone from the aerial parts of Anthemis melanolepis L

V. Saroglou; A. Karioti; H. Skaltsa

doi:10.1055/s-0028-1084428

Planta Medica, Table of Contents

A new sesquiterpene lactone from the aerial parts of Anthemis melanolepis L

V Saroglou ¹, A Karioti ¹, H Skaltsa ¹

¹Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71, Athens, Greece

Abstract

Continuing our research on the chemical constituents from the aerial parts of Anthemis melanolepis L., a Greek endemic species belonging to the section Cota [1], we report here the isolation and identification of a new sesquiterpene lactone. The isolation was proceeded according to the Bohlmann isolation method, slightly modified [2]. The structure of the isolated compound 1 was elucidated by spectroscopic methods, particularly high-field NMR spectroscopy (¹H-NMR, ¹H-¹H COSY, NOESY, HSQC, HMBC). Compound 1, namely anthemin C, is a new naturally occurring eudesmanolide. Besides compound 1, there were also isolated twelve known sesquiterpene lactones, one terpene, one triterpene, eight flavonoids and three phenolic acids.

Aknowledgments: This project is co-financed within Op. Education by the ESF (European Social Fund) and National Resources.

References: 1. Davis, P. H. (1975) Flora of Turkey and the East Aegean islands. Edinburgh. 5:174–221. 2. Bohlmann, F. et al. (1984) Phytochemistry 23:1979–88.