Planta Med 2008; 74 - PB78
DOI: 10.1055/s-0028-1084423

Alkaloids and phenolic compounds from Acronychia laurifolia

E Kouloura 1, M Halabalaki 1, MC Lallemand 2, F Tillequin 2, AL Skaltsounis 1
  • 1Laboratory of Pharmacognosy & Natural Products Chemistry, Faculty of Pharmacy, Panepistimioupolis, Zografou, 15771, Athens, Greece
  • 2Laboratoire de Pharmacognosie de l' Université René Descartes, UMR au CNRS No 8638, Faculté de Pharmacie, 4 Avenue de l' Odservatoire, F-75006 Paris, France

Acronychia laurifolia Bl. (Rutaceae) is a tree growing in tropical regions [1]. It is well documented for the occurrence of phenolics and alkaloids. Initially, an extraction with diethylether was performed; from which acronyline (1) and acrovestone (2) were isolated [2]. Then a typical protocol for alkaloids was followed and tree extracts were obtained. From the diethylether extract after the alkalization, four alkaloids from the group of furanoquinoleines were isolated and determined as dictamnine (3), pteleine (4), evolitrine (5), kokusaginine (6) [3]. All metabolites mentioned above were structurally characterized with spectral methods (IR, MS, and NMR 1D/2D). The cytotoxic activity of the isolated metabolites is under investigation.

References: 1. Hartley TG. (1974) A revision of the genus Acronychia (Rutaceae) J. Arnold Arbor. Harv. Univ. 55.

2. Shung, TS. et al (1989)J. Nat. Prod. 52:1284–1289.

3. Pusset, J. et al (1991) Planta Med. 57:153–155.