Planta Med 2008; 74 - PB76
DOI: 10.1055/s-0028-1084421

Rotenoid derivatives and other constituents of the twigs of Millettia duchesnei De Wild

F Ngandeu 1, M Bezabih 2, D Ngamga 1, AT Tchinda 3, BT Ngadjui 4, BM Abegaz 2, H Dufat 5, F Tillequin 5
  • 1Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon
  • 2Department of Chemistry, Faculty of Science, University of Botswana, Private Bag 00704, Gaborone, Botswana
  • 3Institute of Medical Research and Medicinal Plants Studies (I.M.P.M), P.O. Box 6163, Yaoundé, Cameroon
  • 4Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon
  • 5Laboratoire de Pharmacognosie U.M.R au C.N.R.S. No. 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Paris 5, 4 Avenue de l'Observatoire-75270, Paris, cedex 06, France

Three new prenylated rotenoids, elliptol (1), 12-deoxo-12α-methoxyelliptone (2) and 6-methoxy-6a,12a-dehydrodeguelin (3) were isolated from the twigs of Millettia duchesnei De Wild. together with the known compounds, 6a,12a-dehydrodeguelin, 6-hydroxy-6a,12a-dehydrodeguelin, 6-oxo-6a,12a-dehydrodeguelin, elliptone, 12a-hydroxyelliptone and eriodictyol. The structures of the novel compounds were elucidated on the basis of spectral data and chemical correlation. In addition, the full NMR data of 6-oxo-6a,12a-dehydrodeguelin and 6-hydroxy-6a,12a-dehydrodeguelin are reported here for the first time.

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Reference: Ngandeu, F. et al. (2008) Phytochemistry 69:258–263.