Planta Med 2008; 74 - PB67
DOI: 10.1055/s-0028-1084412

Antileishmanial constituents of the panamanian endophytic fungus Phoma herbarum strain M16

S Martínez-Luis 1, G Della-Togna 2, WH Gerwick 3, L Cubilla-Rios 4
  • 1Smithsonian Tropical Research Institute, Unit 0948, APO AA 34002–0948
  • 2Instituto de Investigaciones Científicas Avanzadas y Servicios de Alta Tecnología, Clayton, Edificio 175, PO Box 7250, Panama
  • 3Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093
  • 4Laboratory of Tropical Bioorganic Chemistry, Faculty of Natural, Exact Sciences and Technology, Apartado 0824–00159, University of Panama, Panama City, Republic of Panama

Bioassay-directed fractionation of the fermentation broth and mycelium of the fungus Phoma herbarum strain M16 led to the isolation of five antileishmanial compounds (1-5), including two novel natural products. Their structures were established by spectral analyses. All metabolites caused significant inhibition of growth of Leishmania donovani amastigotes with IC50 values of 0.12, 3.93, 1.34, 8.4 and 0.62µM, respectively

1

2 R1=O, R2=OH and R3=H 3 R1=O, R2=OH and R3=OH 5 R1=OH, R2=OH and R3=H

4