Planta Med 2008; 74 - PB59
DOI: 10.1055/s-0028-1084404

Secondary metabolites from anatolian endemic Centaurea ensiformis

Ş Baykan Erel 1, S Demir 1, C Karaalp 1, IA Khan 2, E Bedir 3
  • 1Ege University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Bornova, 35100, İzmir, Turkey
  • 2National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, U.S.A
  • 3Ege University, Faculty of Engineering, Department of Bioengineering, Bornova, 35100, İzmir, Turkey

The genus Centaurea is represented by 187 species in the flora of Turkey [1]. Centaurea ensiformis is a Mediterranean endemic species localized in Mugla, South West Anatolia. In continuation of our phytochemical studies on Centaurea species, here we report on the constituents of C. ensiformis, which has not been investigated before.

Methanol extract of the aerial parts (15g) was partitioned with n-butanol. Butanolic extract was fractionated by using chromotographic methods (CC-sephadex, silica, VLC-RP-18, and preparative TLC). In addition to known compounds scopolin, picein, syringin and (3S, 5R, 6R,7E,9S)-megastigman-7-ene-3,5,6,9-tetrol 3-O-β-D-glucopyranoside, a new neolignan glycoside was also isolated (1).

The structure elucidation of the compounds was achived by one and two dimensional NMR techniques and high resolution mass spectrometry.

References: 1. Davis, P.H., Mill, R.R. (1988) Flora of Turkey, Volume 5, Edinburgh University Press, 465. 2.