Planta Med 2008; 74 - PB19
DOI: 10.1055/s-0028-1084365

New Clerodane diterpene from the twigs of Casearia obliqua (Salicaceae)

GMJ Vieira 1, TO Gonçalves 1, LO Regasini 1, PMP Ferreira 2, LV Lotufo 2, C do Ó Pessoa 2, VS Bolzani 1, AJ Cavalheiro 1
  • 1São Paulo State University, Araraquara, SP, Brazil
  • 2Federal University of Ceará, Fortaleza, CE, Brazil

The genus Casearia is a rich source of clerodane-type diterpenoids [1–3]. Many of these diterpenoids possess cytotoxic and antimalarial activities [2–4]. The literature does not report studies of the species Casearia obliqua. The EtOH extract of this species was selected for fractionation based on cytotoxicity assay against SF-295, HCT-8 and MDA/MB-435 cell human tumors. Fractionation of the extract by Sephadex LH-20 and reverse-phase C18 HPLC yielded one new diterpene caseobliquin A. Caseobliquin A was identified by spectroscopic methods (UV, NMR 1H and 13C –1D and 2D). This compound differs from casearborin E [3] on stereochemistry of carbon C2 and C19.

Caseobliquin A

Acknowledgements: UNESP, CNPq, FAPESP.

References: 1. Santos, A. G. et al. (2007) Quim. Nova. 30: 1100–1103.

2. Shen, Y-C. et al. (2004)J. Nat. Prod. 67: 316–321.

3. Beutler, J. A. et al. (2000)J. Nat. Prod. 63: 657–661.

4. Kanokmeddhakul, S. et al. (2005)J. Nat. Prod. 68: 183–188.