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Planta Med 2008; 74 - PB16
DOI: 10.1055/s-0028-1084362
DOI: 10.1055/s-0028-1084362
Structure and biological activity of coumaquinoline A from Toddalia asiatica. First isolation of a naturally-occurring quinolone-coumarin dimer
In a search for novel bioactive natural products from plant sources, we isolated a novel quinolone-coumarin dimer named coumaquinoline A from leaves of Toddalia asiatica (L.) Lam. (Rutaceae). Structure 1 was established on the basis of spectroscopic (HMBC, NOE, and MS) and synthetic methods. In a biological test of cytotoxicity against HL-60 cells, natural product 1 showed no activity. However, synthetic regio-isomer 2 showed significant cytotoxicity induced by apoptosis through the activation of the caspase-9 and caspase-3 pathways triggered by mitochondrial dysfunction.