Planta Med 2008; 74 - PB9
DOI: 10.1055/s-0028-1084356

Cytotoxic and anti-plasmodial activities of constituents of Pentadesma butyracea

F Zelefack 1, MG Dijoux-Franca 2, D Guilet 2, S Ngouela 1, B Lenta 1, N Fabre 3, E Tsamo 1
  • 1University of Yaoundé, Faculty of Science, Department of Organic Chemistry, P.O. Box 812, Yaoundé, Cameroon
  • 2Université Lyon 1, ISPB, UMR 5557 CNRS, Ecologie Microbienne, 69373 Lyon, France
  • 3Université Toulouse 3, Faculté des Sciences Pharmaceutiques, UMR 152 IRD-UPS, 31062 Toulouse, France

Four new xanthone derivatives, named butyraxanthone A (1), B (2), C (3) and D (4), have been isolated from the stem bark of Pentadesma butyracea (Clusiaceae), together with six known xanthones [1,2] and one triterpenoid (lupeol). The structural elucidation of the new compounds was established on the basis of 1D and 2D NMR and HR-EIMS spectroscopic analysis. The anti-plasmodial activities of these compounds were evaluated, in culture against FCB1 strain of Plasmodium falciparum parasites. (IC50 of 3.0 and 2.7µg/mL for compounds 1 and 2 respectively). Compound 4 showed a potent cytotoxic activity against MCF-7 cells with an IC50 value of 1.3µg/mL.

Acknowledgements: The authors thank the „Agence Universitaire de la Francophonie (A.U.F.)“ for fellowship awarded to F. Zelefack at University Lyon I, France.

References: 1. Suksamrarn, S. et al. (2006) Chem. Pharm. Bull. 54: 301–305.

2. Panthong, K. et al. (2006) Phytochemistry 67: 999–1004.