Planta Med 2008; 74 - PB6
DOI: 10.1055/s-0028-1084353

Two new triterpenes from the rhizome of Dryopteris crassirhizoma, and inhibitory activities of its constituents on Human Immunodeficiency Virus-1 protease

JS Lee 1, 2, H Miyashiro 2, N Nakamura 2, M Hattori 2
  • 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea
  • 2Research Institute for Natural Medicine (Wakan-Yaku), University of Toyama, Japan

Two new hopane type triterpenes, named dryopteric acids A (1) and B (2), were isolated from the rhizome of Dryopteris crassirhizoma Nakai (Dryopteridaceae) together with sixteen known compounds. Of isolated compounds, ursolic acid, and dryopteric acid A (1) and B (2) showed potent inhibitory activities against HIV-1 protease with IC50 values of 8.9–44.5µM. In addition, the acetylated derivatives of compounds 1 and 2 appreciably increased inhibitory activities with their IC50 values of 1.7 and 10.8µM, respectively.

dryopteric acid A (1)

dryopteric acid B (2)

Acknowledgements: This work was supported by the Korea Research Foundation (KRF) through the program of Overseas Post-doctoral Fellowships (M01–1999–000–12172–0) and by University of Toyama.

References: 1. Min, B.S. et al. (2001) Chem Pharm Bull 49:546–50.

2. Ma, C. et al. (1999) Chem Pharm Bull 47:141–5.