The potential analgesic and anti-inflammatory activities of Panax ginseng head BuOH fraction in vivo
Panax ginseng (P. ginseng) has been widely used for many traditional medicinal therapies in Korea and Japan. Oral administration of P. ginseng-head BuOH fraction (PGHB) was found to be safe in acute toxicity (LD50>5,000mg/kg). PGHB inhibited the partially acetic acid-induced writhes (approximately 32%, P<0.05) in mice. This result indicates that PGHB possess antinociceptive activity in chemical-induced pain test models. PGHB (500mg/kg) strikingly inhibited acetic acid-induced extravasation of Evans blue dye in mice by approximately 20.6% (P<0.05), and similar to suppressive effect of ibuprofen (27.7%) as a positive control drug. Also, PGHB reduced approximately 4.55% of carrageenan-induced paw edema at 3h after oral administration. In CIA mice, PGHB suppressed the production of serum IL-6. This suggests that it is concluded that PGHB has potential analgesic and anti-inflammatory activities, and will be supporting the evidence for the potential anti-rheumatoid activity of Korean P. ginseng head.