Planta Med 2008; 74 - PA267
DOI: 10.1055/s-0028-1084265

Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts

CW Lee 1, HS Kim 1, HJ Choi 1, JW Kim 1, HK Kim 1, HT Moon 2, ER Woo 2
  • 1R & D Center, Amore-Pacific Corporation, 314–1, Bora-dong, Kiheung-gu, Yongin-si, Kyounggi-do 449–729, South Korea
  • 2College of Pharmacy, Chosun University, Gwnagju 501–759, South Korea

The methanol extract of Selaginella tamariscina significantly inhibited UV irradiation induced activity of matrix metalloproteinase-1 (MMP-1) in primary fibroblasts from human skin. Using a bioassay-directed chromatographic separation, five biflavonoids were isolated from the ethyl acetate soluble fraction of S. tamariscina. Here, we investigated the effect of these five biflavonoids on the regulation of MMP-1 and -2 in UV irradiated cultured dermal fibroblasts from human neonatal foreskins. Among these biflavonoids, sumaflavone (2) and amentoflavone (4) showed significant MMP-1 inhibitory activity. The IC50 values of sumaflavone, amentoflavone and retinoic acid, which was used as a positive control, were 0.78, 1.8, and 10µM, respectively [1].

References: 1. Lee, CW et al. (2008) Bioorganic & Medicinal Chemistry 16:732–738.