Oroxylin A has an awakening effect, and it also alleviates ADHD behavior in SHR
Oroxylin A is a flavonoid isolated from Scutellaria baicalensis, which is one of the most important medicinal herbs in traditional Korean medicine. In this study, we investigated the psychopharmacological effects of oroxylin A, using open field test, rotarod test, balanced wire test, sleeping test in mice. Oroxylin A significantly increased moved distance and rearing frequency in center area, and also increased running time on rotarod, duration time on wire. It also significantly increased onset time and decreased duration time in sleeping test (Figure). Because oroxylin A blocked thiopental-induced sleeping, we studied its awakening effect and other advantages. Oroxylin A antagonized the muscimol (GABAA receptor agonist)-induced Cl- current and its action is similar with bicuculline (GABAA receptor antagonist). We also screened the effects of oroxylin A on attention-deficit/hyperactivity disorder (ADHD) using Spontanously Hypertensive Rat (SHR) and Wistar Kyoto Rat (WKY). SHR showed hyperactivity and inattention behavior compared to WKY, but this behavior alleviated by oroxylin A administration.
Acknowledgements: This research was supported by KFDA grant (S-06–02–2-CHM-230–0-B)
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