Hypoglycemic, anti-inflammatory and cytotoxicity evaluation of aqueous and organic extracts from Ibervillea lindheimeri (A. Gray) Greene
In the mexican traditional medicine, the „güereque“ remedy comprises several species of Ibervillea genus and it is used against diabetes and cancer. One of these species, I. lindheimeri is specially used for diabetes. Although it is widely used, to our knowledge, no reports related to its pharmacology or chemical composition have been published. Therefore, we decided to evaluate the hypoglycemic, anti-inflammatory and cytotoxic activities of some extracts from this species. The results showed that, although both, aqueous (ae) and methanol (me) extracts produced hypoglycemic effects (200mg/kg, i.p.), only me was statistically significant at 3, 6, 12 (p<0.01) and 24h (p<0.05) after its administration. On the other hand, oral administration of the ethyl acetate extract (100mg/kg), showed a significant 82% anti-inflammatory activity in the tpa-induced ear edema in mice model . At the same dose it showed in the carrageenan-induced hind paw edema in rats test at 1 and 3h following administration statistical anti-inflammatory activity, however, at 5h after its administration this extract showed a 100% of inhibition of edema (p<0.05). Besides, the hexane extract from the bark showed cytotoxic effects against the human U251, PC3, K562, HCT15 and Skul1 cancer cell lines.
References: 1. García-Argáez et al. (2000) Planta med. 66: 279–281