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Antidepressant effect of an alkaloid extract from Annona cherimolia
Some Annona species have been used in traditional medicine as sedative and tranquilizing remedies. Previous studies indicated that Annona diversifolia and A. muricata possess anxiolytic and antiepileptic effects . On the other hand, the Annonas species, synthesize alkaloids, mainly of isosquinoline, aporphine, and oxo-aporphine type, some of these compounds showed affinity to 5HT1A receptors in vitro experiment. Taking it into account, we decide evaluate the antidepressant effect of the total alkaloids extract from the leaves of Annona cherimolia in the forced swimming mice test. To discard nonspecific effects, such as hyperactivity and sedation, the locomotors activity of the experimental subjects, in the field open test, was evaluated. The results showed that the total alkaloids extract of the leaves of A. cherimolia possess a significant antidepressant effect, in mice at 10 and 20mg/kg doses, without producing side effects on locomotors activity. On the other hand, the phytochemical analyses let isolation of the liriodenine and anonaine as main products. The biological evaluation of the isolates is in progress.
References: 1. López-Rubalcava, C. et al (2006) Life Sci. 78:730–737.