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Effect of HTE001, a herbal formulation on elicitation of penile erection and anti-fatigue effect in the rats
This study was conducted to investigate the effect of HTE001, a new herbal mixture of 9 herbs in improving erectile dysfunction (ED) and its anti-fatigue effects. HTE001 was extracted by boiling for 6 hr with a 70% ethanol. The 70% ethanol extract was filtered and evaporated to dryness and then stored at -20°C. To investigate the effect of HTE001 on penile erection, the electrostimulation method using rat was performed. The intracavernous pressure (ICP) and mean arterial blood pressure (MAP) were simultaneously monitored after electric cavernous nerve stimulation before and after the administration of HTE001 (30, 100, 300mg/kg). The maximum ICP/MAP ratio was determined by selecting the highest value of the ICP/MAP ratio during a 5-minute period. The cumulative area under the curve (AUC) (time x ICP/MAP ratio) from 1min. Before the initiation of electrostimulation to the restabilization period (total 5min) was calculated. The maximum ICP/MAP ratio of the HTE001 300mg/kg group after nerve simulation were significantly (***P<0.001) increased compared to the control group (64.5±7.8% vs. 45.4±7.5%). The HTE001 300mg/kg significantly elevated the AUC value more than the control group (6605±898 vs. 5070±626). The anti-fatigue effect of HTE001 was assessed by submerged times during forced swimming. The control group showed significantly (**P<0.01) longer submerged time than the HTE001 300mg/kg administered group (21.6±5.2 vs.12.8±2.9) during forced swimming. So, HTE001, a new herbal formula, shows an erectile function enhancing effect as well as anti-fatigue effect in normal animals.
Acknowledgements: Grant (PF 06203–00) of Plant Diversity Research Center of 21st Century Frontier Research Program (Ministry of Science and Technology, Korea), Second Stage of Brain Korea 21 Project (Ministry of Education, Korea).
References: 1. Chen, K.K. et al. (1992)J. Urol. 147: 1124–1128.