Anti-inflammatory effects of schisandrin on modulation of NF-κB, JNK and p38 MAP kinases
Schisandrin is the main active lignan isolated from Schisandra chinensis Baill. (Schisandraceae). Recent studies have demonstrated that schisandrin exhibits anti-inflammatory effects in vivo and in vitro . In this study, we found that the anti-inflammatory mechanisms are not totally the same according to whether macrophages are pretreated with schisandrin before LPS (Lipopolysaccharide) or not. Schisandrin (50µM) increased the activation of JNK and p38 by transient stimulation of LPS and decreased the activation of those two by persistent stimulation of LPS. Moreover, schisandrin (50 and 100µM) inhibited the activation of NF-κB. These results suggest that schisandrin might be involved in anti-proliferation of cells. The data also demonstrate that schisandrin inhibits proliferation of A549 cancer cells through modulating p38 and JNK activation and reducing ERK activation  http://www.ncbi.nlm.nih.gov/sites/entrez? Db=pubmed&Cmd=Search&Term=%22Ip SP%22%5B Author%5D&itool=EntrezSystem2. PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus.
Acknowledgement: This work was supported by a grant from the Korea Food and Drug administration for Studies on the Identification of the Efficacy of Biologically Active Components from Oriental Herbal Medicines (2007).
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