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The anti-staphylococcal activity of new diterpenes from Pycnostachys urticofolia
The increasing incidence of infection and deaths caused by the emergence and spread of methicillin-resistant Staphylococcus aureus (MRSA) has been comprehensively observed and recorded worldwide [1,2]. Ongoing phytochemical studies on medicinal plants from the Lamiaceae family, has resulted in the isolation of anti-staphylococcal metabolites from Pycnostachys urticifolia. This genus is represented by 81 species and is traditionally used in the treatment of high blood pressure and a number of gastrointestinal conditions .
From the aerial parts of this species, five known compounds and two new diterpenes were isolated. The structures of these natural products were elucidated from a series of 1D and 2D NMR experiments. Both compounds were determined to be substituted 17(15→16) abeo-abietanes. The anti-staphylococcal activity of these metabolites was assessed against a panel of standard and multi-drug resistant (MDR) S. aureus strains with minimum inhibitory concentrations (MICs) ranging from 64–512µg/ml.
Acknowledgements: Stiefel Laboratories.
References: 1. European Antimicrobial Resistance Surveillance System (2006), Annual Report (2006) 2. Centers for Disease Control and Prevention. (2007). Emerging Infectious Diseases 13, 12. 3. Leistner O.A (2000) Seed plants from Africa: families and genera. Strelitzia 10